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KMID : 1007020050030010054
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Korean Soceity of Osteroporosis
2005 Volume.3 No. 1 p.54 ~ p.61
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The Effects of Cdx-2 Polymorphism in the Promoter Region of the Vitamin D Receptor Gene on Bone Mineral Density in Postmenopausal Korean Women
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Kim Se-Hwa
Rhee Yu-Mie
Park So-Young
Kim Dol-Mi
Lee Si-Hoon
Ahn Chul-Woo
Cha Bong-Soo
Kim Kyung-Rae
Lee Hyun-Chul
Lim Sung-Kil
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Abstract
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Objectives: The intestine-specific transcription factor Cdx-2 played an important role in the transcription of the human vitamin D receptor(VDR) gene. The objective of this study was to investigate the relationship between the Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene and the bone mineral density(BMD) in postmenopausal Korean women.
Methods: We enrolled 150 healthy postmenopausal women. The bone mineral density at the lumbar spine and proximal femur were measured by dual energy X-ray absorptiometry. The polymorphism was analyzed in the core sequence 5’-ATAAAAACTTAT-3’ in the Cdx-2 binding site in the VDR gene promoter(Cdx-2 polymorphism).
Results: In 150 postmenopausal women, 30 were genotype Cdx-A(adenine at -3731 nucleotides relative to the transcription start site of human VDR gene 5’-ATAAAAACTTAT-3’), 54 were genotype Cdx-G(guanine at -3731 nucleotides, 5’-GTAAAAACTTAT-3’), and 66 were genotype Cdx-AG(heterozygote). A significant intergroup difference in BMD was not found at the lumbar spine and proximal femur among the different genotypes(p=ns). There was no difference in distribution of the Cdx-2 genotype between the osteoporosis and control group(?2=1.76, P=0.415). Even in the individuals with a low calcium intake(daily calcium intake less than 400mg), there was no association of Cdx-2 genotype with lumbar spine BMD or proximal femur BMD.
Conclusion: These results showed that there was no significant effect of Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene on BMD in postmenopausal Korean women.
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KEYWORD
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Cdx-2, Cdx-2 Polymorphism, Vitamin D Receptor Gene, Bone Mineral Density
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